Nkhani

Poyang'anizana ndi COVID-19 yomwe ikusintha mosalekeza, njira zachikhalidwe zothanirana nazo sizothandiza.
Pulofesa Huang Bo ndi gulu la Qin Chuan la CAMS (Chinese Academy of Medical Science) adapeza kuti ma macrophages omwe amawunikira kwambiri anali njira zowongolera matenda a COVID-19, ndipo adapeza mankhwala awiri omwe amagwiritsidwa ntchito kwambiri pamtundu wa COVID-19.Zotsatira za kafukufuku wofunikira zimasindikizidwa pa intaneti mu nyuzipepala yapadziko lonse lapansi yamaphunziro, kutulutsa mazizindikiro ndi chithandizo chomwe mukufuna.
"Phunziroli silimangopereka chithandizo chotetezeka komanso chothandiza ku COVID-19, komanso kuyesa molimba mtima 'kugwiritsa ntchito mankhwala akale kuti agwiritse ntchito mwatsopano', kupereka njira yatsopano yoganizira kusankha mankhwala a COVID-19."Huang Bo anatsindika poyankhulana ndi mtolankhani wa sayansi ndi zamakono tsiku ndi tsiku Pa April 7th.
Monga baluni, alveoli ndi gawo lofunikira la mapapo.Mkati mwa alveoli amatchedwa pulmonary surfactant layer, yomwe imakhala ndi mafuta ochepa komanso mapuloteni kuti alveoli ikhale yotalikirapo.Nthawi yomweyo, nembanemba ya lipid iyi imatha kudzipatula kunja kuchokera mkati mwa thupi.Mamolekyu a mankhwala a magazi, kuphatikizapo ma antibodies, alibe mphamvu yodutsa mulingo wa alveolar.
Ngakhale kuti alveolar surfactant layer imalekanitsa kunja ndi mkati mwa thupi, chitetezo chathu cha mthupi chimakhala ndi gulu lapadera la phagocyte, lotchedwa macrophages.Ma macrophages amalowa mu alveolar surfactant wosanjikiza ndipo amatha phagocytize particles ndi tizilombo toyambitsa matenda zomwe zili mu mpweya wopumira, kuti mukhalebe aukhondo wa alveoli.
"Chifukwa chake, COVID-19 ikalowa mu alveoli, alveolar macrophages amakulunga tinthu tating'onoting'ono ta kachilomboka pamaselo awo ndikumeza mu cytoplasm, yomwe imatsekereza ma vesicles a kachilomboka, omwe amatchedwa endosomes."Huang Bo adati, "ma endosomes amatha kutumiza tinthu tating'onoting'ono ta ma lysosomes, malo otayira zinyalala mu cytoplasm, kuti awononge kachilomboka kukhala ma amino acid ndi ma nucleotide kuti agwiritsenso ntchito ma cell."
Komabe, COVID-19 imatha kugwiritsa ntchito ma macrophages enieni a alveolar kuthawa ma endosomes, ndikugwiritsanso ntchito macrophages kuti azidzibwereza okha.
"Zachipatala, ma bisphosphonates monga alendronate (AlN) amagwiritsidwa ntchito pochiza osteoporosis poyang'ana macrophages;mankhwala a glucocorticoid monga dexamethasone (DEX) ndi mankhwala omwe amagwiritsidwa ntchito kwambiri poletsa kutupa.”Huang Bo adati tapeza kuti DEX ndi AlN amatha kuletsa kuthawa kwa kachilomboka kuchokera ku endocytosomes poyang'ana mawu a CTSL ndi pH ya endosomes motsatana.
Popeza kasamalidwe kazinthu kamakhala kovuta kutulutsa chifukwa cha kutsekeka kwa gawo logwira ntchito la alveoli, Huang Bo adati zotsatira za kuphatikiza kotereku zimatheka kudzera kutsitsi pang'ono.Panthawi imodzimodziyo, kuphatikiza uku kungathenso kugwira ntchito ya hormone anti-inflammatory.Mankhwala opopera awa ndi osavuta, otetezeka, otsika mtengo komanso osavuta kulimbikitsa.Ndi njira yatsopano yowongolera matenda a COVID-19.